我写了一篇是 某个lncRNA诊断不同肿瘤的meta分析，审稿人提了一个问题，Moreover, the source of circulating non-coding RNAs, including lncRNAs and others, is very heterogeneous, and it must be one of the important reasons related with the heterogeneity observed by the authors. I sincerely think that the paper must be completed including a proper discussion of this fact, taking into account the binomial distribution of circulating/non-circulating ncRNAs.我写的是特定lncRNA的常规诊断meta分析，审稿人为啥问我循环ncRNA,其次后面提到的二项分布是什么意思，审稿人是问错了么？如果没错，那该如何从哪方面回答审稿人