临床研究有主要结局和次要结局,对结果分析时,需不需要进行多重校正

临床研究有主要结局和次要结局,审稿人的意见是需要进行多重校正,不知道这个该怎么进行,有大神辅导一下吗?原话是:A huge number of statistical comparisons were performed for the primary and secondary outcomes, with no hierarchization or adjustment for multiple testing. Furthermore, according to the methods section, both log rank test and Cox proportional hazards models were used to evaluate the primary outcomes.